Simulation of triacylglycerol ion profiles: bioinformatics for interpretation of triacylglycerol biosynthesis
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چکیده
منابع مشابه
Simulation of triacylglycerol ion profiles: bioinformatics for interpretation of triacylglycerol biosynthesis.
Although the synthesis pathways of intracellular triacylglycerol (TAG) species have been well elucidated, assessment of the contribution of an individual pathway to TAG pools in different mammalian organs, particularly under pathophysiological conditions, is difficult, although not impossible. Herein, we developed and validated a novel bioinformatic approach to assess the differential contribut...
متن کاملDGAT enzymes and triacylglycerol biosynthesis
Triacylglycerols (triglycerides) (TGs) are the major storage molecules of metabolic energy and FAs in most living organisms. Excessive accumulation of TGs, however, is associated with human diseases, such as obesity, diabetes mellitus, and steatohepatitis. The final and the only committed step in the biosynthesis of TGs is catalyzed by acylCoA:diacylglycerol acyltransferase (DGAT) enzymes. The ...
متن کاملDoes triacylglycerol biosynthesis require diacylglycerol acyltransferase (DAGAT)?
Microsomal membrane preparations from the developing seeds of sunflower (Helianthus annuus L.) catalyse the conversion of sn-glycerol-3-phosphate and acyl-CoA to triacylglycerol via phosphatidic acid and diacylglycerol. The formation of diacylglycerol from phosphatidic acid was Mg2+ dependent and in the presence of EDTA phosphatidic acid accumulated. This property was used to generate large qua...
متن کاملControl of hepatic triacylglycerol metabolism.
Avigan, J., Williams, C. D. & Blass, J. P. (1970) Biochim. Biophys. Acta 218,381-384 Betteridge, D. J., Higgins, M. J. P. & Galton, D. J. (1975) Br. Med. J . 4,5W502 Brown, M. S. & Goldstein, J. L. (1976) Science 191,150-154 Brown, M. S., Faust, J. R. & Goldstein (1975) J. Clin. Invest. 55, 783-793 Christophe, J. & Popjhk, G. (1961) J. Lipid Res. 2,244-257 Danielsson, H. (1972) Steroids 20,63-7...
متن کاملIdentification of a Distinct, Cutin-Related Pathway for Biosynthesis of Triacylglycerol Lipids in Bayberry.
Plants produce wax and other extracellular lipids on the epidermis, as part of the pollen exine, but produce triacylglycerol (TAG) intracellularly in seeds such as soybean (Glycine max), and in fruits such as avocado (Persea americana). By contrast, the fruit of Bayberry (Myrica pensylvanica), a North American shrub, accumulates wax like no other fruit (figure), producing an external layer of w...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2013
ISSN: 0022-2275
DOI: 10.1194/jlr.m033837